• 产品名称：37450动态足底触觉仪
• 订货号：tlyon000402
• 品牌名称：意大利Ugo

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37450 - 动态足底触觉仪

动态足底触觉仪是用以自动评估啮齿类动物跖面的“触觉感应”。它与电子触觉测量（Electronic Von Frey ）和足底触觉测量（Plantar Von Frey ）类似，不同之处在于它能记录持续时间和爪缩回时的作用力。

可移动的触觉刺激装置放于实验动物足底，可根据实验人员需要设定力的大小和力增大的速度等。

触觉测量套件（ Von Frey ）以每次增加直径0.05mm的细丝增加施力，直到受试动物的爪抽搐。

动态足底触觉计的新模式为：

一台可移动的触觉刺激装置，配备刺激丝和可调整角度的镜子；

实为一微电子处理单位，提供数字显示、内部数据存储、可用闪存导出数据、可外接打印机；

宽敞的实验操作平台；

模块化的动物笼，可自由组合3-12个隔间。

特征	优点
仪器自动施力	施力速度、方向等保持一致性
操作人员只需按动开关	相比用Von Frey测试，本实验时间短，且操作人员不会感到沉闷
力的大小和增加量可预置	更多参数符合实验需要

规格：

开始：	软键
可设力范围：	0 - 50.0 g, 分辨率为0.5 g
可设力增加率：	1 - 50 s, 分辨率为1s
着力丝移动范围；	12 mm
实验时间：	液晶屏显示，分辨率为0.1s
连接电脑：	DELTA 9-pin 连接线
电源： 规格： 动物罩子：	85-264 VAC - 50-60Hz - 20 W max 85 x 40 x 40 cm 3个，每个20x20x14(h) cm
净重：	12.50 Kg.
毛重： 包装规格：	约21.50 Kg 98x49x47cm

附件：

37000-145：	面板内嵌式热敏打印机
57145： 37450-278 37100	微型热敏打印机 外加刺激，穿孔平台和动物保护罩 两组Durham动物抓持器，针对面部疼痛实验

参考文献：

提及动态足底触觉仪的文献：

- R. Lu, A. Schmidtko: “Direct Intrathecal Drug Delivery in Mice for Detecting In Vivo Effects of cGMP on Pain Processing” Methods in Molecular Biology 1020: 215-221, 2013

- I.Q. Russe et alia: “Activation of the AMP-Activated Protein Kinase Reduces Inflammatory Nociception” Journal of Pain 2, 2013

- J. Btesh et alia: “Mapping the Binding Site of TRPV1 on AKAP79: Implications for Inflammatory Hyperalgesia” J. Neuroscience 33 (21): 9184-9193, 2013

- V. Brázda et alia: “Dynamic Response to Peripheral Nerve Injury Detected by In Situ Hybridization of IL-6 and its Receptor mRNAs in the Dorsal Root Ganglia is not Strictly Correlated With Signs of Neuropathic Pain” Molecular Pain 9(42), 2013

- V. Shunmugavel et alia: “Simvastatin Ameliorates Cauda Equina Compression Injury in a Rat Model of Lumbar Spinal Stenosis” J. Neuroimmune Pharmacology 8 (1): 274-286, 2013

- O. Coste et alia: “The p21-activated kinase PAK 5 is involved in formalin-induced nociception through regulation of MAP-kinase signaling and formalin-specific receptors” Behavioural Brain Research 234 (1): 121-128, 2012

- M.K. Boettger et alia: “Differential Effects of Locally and Systemically Administered Soluble Glycoprotein 130 on Pain and Inflammation in Experimental Arthritis” Arthritis Research & Therapy 12 (R140): 1-9, 2010

- A.L.M. Scott and M.S. Ramer: ” Schwann Cell p75NTR Prevents Spontaneous Sensory Reinnervation of the Adult Spinal Cord” Brain: 1-12, 2010

- M. Rosemann et alia: “Microphthalmia, Parkinsonism, and Enhanced Nociception in Pitx3416insG Mice” Mamm Genome 21: 12-27, 2010- D. Piomelli et alia:” Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism”.Nature NSC, 2010

- L. Ramer et alia: "Rho-Kinase Inhibition Enhances Axonal plasticity and Attenuates Cold Hyperalgesia after Dorsal Rhizotomy" J. Neuroscience, 24 (48), 10796-10805, 2004

- E. Escribano et alia: "Rapid Human Skin Permeation and Topical Anaesthetic Activity of a New Amethocaine Microemulsion" Skin Pharmacol. Physiol., 18, 294-300, 2004

- G. Villetti et alia: "Antinociceptive Activity of the N-Methyl-D-aspartate Receptor Antagonist N-(2-Indanyl)-glycinamide Hydrochloride (CHF3381) in Experimental Models of Inflammatory and Neuropathic Pain" J. Pharmacol. Exper. Therap., 306, 804-814, 2003

- M. Isabel Arévalo et alia: "Thermal Hyperalgesia and Light Touch Allodynia After Intradermal Mycobacterium butyricum Administration in Rat" Inflammation, 27 (5), 293-299, 2003

Durham Holders for Orofacial Stimulation

- F.G. Garrett, P.L. Durham et alia: “Validation of a Novel Rat-Holding Device for studying heat- and mechanical-Evoked Trigemi­nal Nocifensive Behavioral Responses” J. Orofacial Pain, 26 (4): 336- 344,2012

- F.G. Garrett, P.L. Durham et alia: “Development of a novel device for measuring withdrawal latency by thermal stimulation in rodent facial pain models using the Hargreaves Plantar Apparatus” Poster presented at SFN 2010