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Anti-Patched抗体,Patched/PTCH抗体相关产品:
Anti-5-HTR1B,5-羟色胺受体1B抗体
Anti-5-HTR2B 抗体
Anti-5-HTR2A 5-羟色胺受体2A抗体
Anti-5-HTT/SERT,5-羟色胺转运蛋白抗体
Anti-5-HTR3 5-羟色胺受体3抗体
Anti-5-HTR4 5-羟色胺受体4抗体
Anti-5-LOX , 5-脂氧合酶抗体
Anti-8-OHdG,8-羟基脱氧鸟苷抗体
Anti-A2AR/Adenosine A2A-R,腺苷A2A受体抗体
Anti-AACT-α1, α-1抗胰*抗体
Anti-AAK1,AP2关联激酶1抗体
Anti-AARS2,丙氨酰tRNA合成酶2抗体
Anti-AARS2 丙氨酰tRNA合成酶2抗体
Anti-AAT,α-1抗*抗体
Anti-AATK,细胞凋亡关联*激酶抗体
Anti-Patched抗体,Patched/PTCH抗体Background: PTCH (Patched protein homolog 1) is a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). PTCH associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal.PTCH has a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis. PTCH is expressed in the adult brain, lung, liver, heart, placenta, skeletal muscle, pancreas and kidney. It is also expressed in tumor cells but not in normal skin. During development PTCH is found in all major target tissues of sonic hedgehog, such as the ventral neural tube, somites, and tissues surrounding the zone of polarizing activity of the limb bud.
Defects in PTCH are probably the cause of basal cell nevus syndrome also known as Gorlin syndrome or Gorlin-Goltz syndrome
Anti-Patched抗体,Patched/PTCH抗体Storage: Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody, the antibody is stable for at least six weeks at 2-4 ℃
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