3D打印磷酸三钙TCP：德国INNOTERE生物材料应用发表文献

INNOTERE Paste-CPC旨在*创伤，重建或矫正干预后未感染的骨缺损。它是世界上di一种可注射的磷酸钙基*糊剂，可作为即用型植入材料提供。一项新颖的，受专li保护的技术取代了对详尽，耗时的术中骨替代水泥的制备，混合和转移的需求。INNOTERE Paste-CPC可以直接使用，可以直接从注射器中使用，也可以通过使用套管将其粘贴到骨骼中。由于INNOTERE Paste-CPC仅在与水性液体接触后才凝固，而不是在注射器中凝固，因此外科医生在施工过程中没有时间限制。自2015年初以来，INNOTERE Paste-CPC即可在欧盟用于临床应用。

• Implant Augmentation for Trochanteric Fractures with an Innovative, Ready to Use Calcium-Phosphate-Cement. Fuchs A, Langenmair E, Hirschmueller A, Suedkamp NP, Konstantinidis L Journal of Orthopaedics and Bone Research 2019

• Incorporation of silicon into strontium modified calcium phosphate bone cements promotes osteoclastogenesis of human peripheral mononuclear blood cells. Wagner AS, Schumacher M, Rohnke M, Glenske K, Gelinsky M, Arnhold S, Mazurek S, Wenisch S Biomedical Materials 2019

• Strontium-modified premixed calcium phosphate cements for the therapy of osteoporotic bone defects. Lode A, Heiss C, Knapp G, Thomas J, Nies B, Gelinsky M, Schumacher M  Acta Biomaterialia 2018

• Ready-to-use injectable calcium phosphate bone cement paste as drug carrier. Vorndran E, Geffers M, Ewald A, Lemm M, Nies B, Gbureck U Acta Biomater 2013

• Properties of injectable ready-to-use calcium phosphate cement based on water-immiscible liquid. Heinemann S, Rössler S, Lemm M, Ruhnow M, Nies B Acta Biomater 2013 

INNOTERE 3D支架是一种合成的，多孔的，生物相容的且具有生物可吸收性的骨替代材料，用于填充或重建不承重的骨缺损或用于填充骨缺损，这些骨缺损已通过适当的方式进行了充分稳定。与传统的预制骨替代品相比，INNOTERE 3D支架的特点是：

• 互连孔隙

• 使用全合成原材料的骨状矿物相

• 可通过骨骼重塑过程吸收

INNOTERE 3D支架的创新功能来自使用INNOTERE创新的磷酸钙*浆的新3D打印技术。该方法允许精确地调节所得支架的互连孔系统的孔隙率。所用的磷酸钙糊剂在印刷过程之后通过特定的固化程序进行固化，无需任何烧结步骤。这样可以避免晶体生长，并导致支架主要由天然骨骼的矿相微晶羟基磷灰石组成。

INNOTERE 3D支架的特定应用领域是：

• 干defect端骨折，例如胫骨，radius骨和肱骨骨折

• 良性肿瘤和囊肿切除后的骨缺损

• 口腔颌面外科的骨缺损

• 填充脊髓笼

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• 3D Plotted Biphasic Bone Scaffolds for Growth Factor Delivery: Biological Characterization In Vitro and In Vivo. Ahlfeld T, Schuster FP, Foerster Y, Quade M, Akkineni AR, Rentsch C, Rammelt s, Lode A, Gelinsky M Advance Healthcare Materials 2019

• Bioprinting of mineralized constructs utilizing multichannel plotting of a self-setting calcium phosphate cement and a cell-laden bioink. Ahlfeld T, Doberenz F, Kilian D, Vater C, Korn P, Lauer G, Lode A, Gelinsky M Biofabrication 2018

• A Methylcellulose Hydrogel as Support for 3D Plotting of Complex Shaped Calcium Phosphate Scaffolds. Ahlfeld T, Koehler T, Czichy C, Lode A, Gelinsky M Gels 2018

• Strontium(II) and Mechanical Loading Additively Augment Bone Formation in Calcium Phosphate Scaffolds. Reitmaier S, Kovtun A, Schuelke J,  Kanter B, Lemm M, Hoess A, Heinemann S, Nies B, Ignatius A Journal of Orthopaedic Research 2017

• In situ functionalization of scaffolds during extrusion-based 3D plotting using a piezoelectric nanoliter pipette. Giron S, Lode A, Gelinsky M  Journal of 3D Printing in Medicine 2016

• 3D plotting of growth factor loaded calcium phosphate cement scaffolds. Akkineni AR, Luo Y, Schumacher M, Nies B, Lode A, Gelinsky M Acta Biomaterialia 2015

• Medium-Term Funkction of a 3D Printed TCP/HA Structure as a New Osteoinductive Scaffold for Vertical Bone Augmentation: A Simulation by BMP-2 Activation. Moussa M, Carrel JP, Scherrer S, Cattani-Lorente M, Wiskott A, Durual S Materials 2015

• A 3D printed TCP/HA structure as a new osteoconductive scaffold for vertical bone augmentation. Carrel JP, Wiskott A, Moussa M, Rieder P, Scherrer S, Durual S Clinical Oral Implants Research 2014

• Fabrication of porous scaffolds by three-dimensional plotting of a pasty calcium phosphate bone cement under mild conditions. Lode A, Meissner K, Luo Y, Sonntag F, Glorius S, Nies B, Vater C, Despang F, Hanke T, Gelinsky M Journal of Tissue Engineering and Regenerative Medicine 2014 

• Well-ordered biphasic calcium phosphate–alginate scaffolds fabricated by multi-channel 3D plotting under mild conditions. Lou Y, Lode A, Sonntag F, Nies B, Gelinsky M Journal of Materials Chemistry B 2013

 磷酸三钙（TCP）是骨骼和牙齿矿物质相的一部分。它构成了临床上用作合成骨移植替代品的大多数无机*的基础。通过标准化的烧结工艺，INNOTERE可以为您提供相纯度≥98％且批次间可重复性的α-TCP粉末或β-TCP粉末。

可根据要求提供无菌粉末，确定粒径的微粉，特殊包装以及用于制造医疗器械的原材料。

• Calcium Phosphate Spacers for the Local Delivery of Sitafloxacin and Rifampin to Treat Orthopedic Infections: Efficacy and Proof of Concept in a Mouse Model of Single-Stage Revision of Device-Associated Osteomyeliti. Trombetta RP, Ninomiya MJ, El-Atawneh IM, Knapp EK, de Mesy Bently KL, Dunman PM, Schwarz EM, Kates SL, Awad HA  Pharmaceutics 2019

• Three dimensional printed calcium phosphate and poly(caprolactone) composites with improved mechanical properties and preserved microstructure. Vella JB, Trombetta RP, Hoffman MD, Inzana J, Awad H, Benoit DSW Journal of Biomedical Materials Research Part A 2018

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