磷酸化CD156b抗体（）

英文名称：    Anti-phospho-ADAM17 （Thr735） 

浓度： 1mg/1ml 

抗体来源： Rabbit

克隆类型：polyclonal 

交叉反应： Human, Mouse, Rat, Pig, Cow, Sheep, 

产品类型: 一抗  

性    状:  Lyophilized or Liquid 

保存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

产品介绍 ：This gene encodes a member of the ADAM （a disintegrin and metalloprotease domain） family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq].

Function : Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway （By similarity）. 
Subunit : Interacts with MAD2L1, MAPK14 and MUC1.
Subcellular Location : Membrane.
Tissue Specificity : Ubiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle, pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney. 
Similarity : Contains 1 disintegrin domain.
Contains 1 peptidase M12B domain. 
Database links : UniProtKB/Swiss-Prot: P78536.1