xona 神经元突触细胞微灌流系统的基底材料的拓扑形貌是影响细胞行为的重要因素之一,细胞与微纳米结构图案表面相互作用研究在细胞生物学、再生医学和组织工程领域具有重要的意义。材料表面微纳米图案化不但可以提供结构模版,用以研究细胞对生长环境的响应特性,而且可以为组织再生用支架和植入性器件的设计提供基础数据。
Description of Neuron Device in DetailNat Methods. 2005 Aug;2(8):599-605.A microfluidic culture platform for CNS axonal injury, regeneration and transport.Taylor AM, Blurton-Jones M, Rhee SW, Cribbs DH, Cotman CW, Jeon NL.100umNeuronThe Neuron Device offered by Xona Microfluidics LLC is fabricated out of optically transparent and biologically inert Polydimethylsiloxane (PDMS). The Neuron Device consists of two chambers connected by microgrooves.The neuron device also makes it possible for the researcher to fluidically isolate cell bodies from axons. The device consists of two chambers connected by a much smaller microgroove barrier. The hydrostatic pressure between the two chambers separated by the microgrooves allows the researcher to fluidically isolate each chamber. This is accomplished by keeping the volumes in the wells on one side of the device higher than the other side of the device. The difference in volume creates hydrostatic pressure thus fluidically isolating each compartment.The total volume of the device is about 600 ul thus the researcher uses less of the expensive reagents typically used in neuronal culture.The neuron device also makes it possible to perform axotomy, cutting axons via vacuum aspiration in the distal chamber and observing their regrowth.xona microfluidics llc snd150 神经元突触细胞微灌流系统xona microfluidics llc snd450 神经元突触细胞微灌流系统xona microfluidics llc snd900 神经元突触细胞微灌流系统xona microfluidics llc TCND500 神经元突触细胞微灌流系统xona microfluidics llc TCND1000 神经元突触细胞微灌流系统xona microfluidics llc RD150 神经元突触细胞微灌流系统xona microfluidics llc RD450 神经元突触细胞微灌流系统xona microfluidics llc RD900 神经元突触细胞微灌流系统xona microfluidics llc ULP 神经元突触细胞微灌流系统
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